Gestational Trophoblastic Neoplasia

• EMA/CO (Etoposide 100 / Dactinomycin 0.5 / Methotrexate 300 / Vincristine 1.0 / Cyclophosphamide 600), Gestational Trophoblastic Neoplasia PID 1607 V1.3 (2026-06-18)
  V1.3: Added MTX level measurement and reference to the glucarpidase protocol. V1.2: Corrected relative times and days for Folinic Acid. V1.1: Cato test done. Removal of folinic acid from antitumor therapy; addition of folinic acid as supportive therapy; creation of the mixed module in fluid intake V1.0: Cato test done
• EMA/CO (Etoposide 100 / Dactinomycin 0.5 / Methotrexate 1000 / Vincristine 1.0 / Cyclophosphamide 600), Gestational Trophoblastic Neoplasia with Brain Metastases PID 1610 V1.3 (2026-06-18)
  V1.3: Added MTX level measurement and reference to the glucarpidase protocol. V1.2: Corrected relative times and days for Folinic Acid. V1.1: Cato test done. Removal of Folinic Acid from antitumor therapy; addition of Folinic Acid as supportive therapy; creation of the mixed module in fluid administration; addition of the Furosemide module V1.0: Cato test done Dosing and duration of infusions according to primary literature

NHL, B-cell type, primary Lymphoma of the central nervous system

• Rituximab 375 / Cytarabin 3000, primäres Lymphom des Zentralnervensystems, Zyklus 4-6 PID 1901 V1.1 (2026-06-18)
  V1.1: Änderung des Titels bezüglich der Erkrankung. V1.0: Cato Test erfolgt. V0.1: Laufzeiten nach der Fachinformation.

NHL, T-cell type, extranodal NK/T-cell Lymphoma, nasal type

• DDGP - Cisplatin 20 / Gemcitabine 800 / PEG-Asparaginase 2500 / Dexamethasone 15, extranodal NK/T-cell Lymphoma PID 2349 V1.1 (2026-06-18)
  V1.1: Correction to indication; removal of infection prophylaxis V1.0: Dosing according to primary literature
• SMILE - Methotrexate 2000 / Ifosfamide 1.5 / Dexamethasone 40 / Etoposide 100 / Asparaginase 6000, extranodal NK/T-cell Lymphoma PID 2351 V1.1 (2026-06-18)
  V1.1: Correction to indication; removal of infection prophylaxis; addition of follow-up visits V1.0: Cato test done V0.1: Dosing and duration based on primary literature.

NHL, T-cell type; other specified NK/T-cell lymphomas

• DDGP - Cisplatin 20 / Gemcitabine 800 / PEG-Asparaginase 2500 / Dexamethasone 15, extranodal NK/T-cell Lymphoma PID 2349 V1.1 (2026-06-18)
  V1.1: Correction to indication; removal of infection prophylaxis V1.0: Dosing according to primary literature
• SMILE - Methotrexate 2000 / Ifosfamide 1.5 / Dexamethasone 40 / Etoposide 100 / Asparaginase 6000, extranodal NK/T-cell Lymphoma PID 2351 V1.1 (2026-06-18)
  V1.1: Correction to indication; removal of infection prophylaxis; addition of follow-up visits V1.0: Cato test done V0.1: Dosing and duration based on primary literature.

Protocols in Revision

Hodgkin Lymphoma

• miniBEAM - Carmustine 60 / Etoposide 75 / Cytarabine 100 / Melphalan 30, Hodgkin Lymphoma PID 2381 V1.1

Multiple Myeloma

• HD 7 - Bortezomib 1.3 / Lenalidomide 25 / Dexamethasone 20, Multiple Myeloma, Induction, Cycle 1-3 PID 40 V1.1
• HD 7 - Lenalidomide 10 / Dexamethasone 20, Multiple Myeloma, maintenance, cycle 1 PID 43 V1.1
• HD 7 - Lenalidomide 10, multiple myeloma, maintenance, cycle 2-3 PID 44 V1.1
• HD 7 - Lenalidomide 15, multiple myeloma, maintenance, cycle 4+ PID 37 V1.1

NHL, B-cell type, primary Lymphoma of the central nervous system

• Cytarabine 2000 / Etoposide 5, primary lymphoma of the central nervous system, cycle 6 PID 1866 V1.1
• MATRIX - Carmustin 400 / Thiotepa 5, primäres Lymphom des Zentralnervensystems, Konsolidierung vor autologer Stammzelltransplantation PID 890 V2.2
• MATRIX - Rituximab 375 / Carboplatin 300 / Ifosfamid 1,5 / Etoposid 100 / Dexamethason 40, primäres Lymphom des Zentralnervensystems, Konsolidierung PID 831 V2.1
• MATRIX - Rituximab 375 / Methotrexat 3500 / Cytarabin 2000 / Thiotepa 30, primäres Lymphom des Zentralnervensystems, Induktion PID 703 V2.2
• Rituximab 375 / Methotrexate 3000 / Procarbazine 60 - Procarbazine 100, maintenance, primary central nervous system Lymphoma PID 1031 V1.3
• Rituximab 375 / Methotrexate 3000 / Procarbazine 60, primary central nervous system Lymphoma, Cycle 1 PID 1191 V1.4
• Rituximab 375 / Methotrexate 3000 / Procarbazine 60, primary central nervous system Lymphoma, cycles 2?3 PID 1030 V2.4