Search Back New search Go to resultsDiseaseMain groupHematologic NeoplasmsSolid TumorsProtocol groupAcute LeukemiasAggressive LymphomasIndolent LymphomasNeuro-OncologyT-Cell and NK-Cell NeoplasmsDiseaseAcute Lymphoblastic LeukaemiaChronic Lymphocytic Leukemia / Small Lymphocytic LymphomaMalignant MeningitisMantle Cell LymphomaNHL, B-Cell Type, Anaplastic Large Cell Lymphoma, ALK-PositiveNHL, B-Cell Type, Burkitt's LymphomaNHL, B-Cell Type, Diffuse Large CellNHL, B-Cell Type, Follicular Grade I-IIIaNHL, B-Cell Type, Follicular grade IIIbNHL, B-Cell Type, IndolentNHL, B-Cell Type, Lymphoblastic LymphomaNHL, B-Cell Type, Mediastinal (Thymic) Large B-Cell LymphomaNHL, T-Cell Type, Lymphoblastic LymphomaSubgroupB-ALLHigh riskLow riskPh/BCR-ABL+Ph/BCR-ABL-T-ALLICD10C79.3C82.-C82.7C82.9C83.1C83.3C83.5C83.7C84.6C85.2C91.0-C91.1-MeSHBurkitt LymphomaLymphoma, Mantle-CellMeningeal CarcinomatosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaSequenceALL,Ph/BCR-ABL+: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375/IMAT800, ALL/NHL, Ph/BCR-ABL+, C1 (PID2084) -|- C2 (PID2085) -|- C3 (PID2086) -|-C4 (PID2085) -|- C5 (PID2087) -|- C6 (PID2088) -|- C7 (PID2089) -|- C8 (PID2090) -|- Month 1-5 (PID2073) -|- Month 6 (PID2110) -|- Month 7 (PID2113) -|- Month 8-17 (PID2073) -|- Month 18 (PID2110) -|- Month 19 (PID2113) -|- Month 20-24 (PID2073)B-ALL: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375, B-ALL/NHL, C1 (PID2061) -|- C2 (PID2064) -|- C3 (PID2061) -|- C4 (PID2064) -|- C5 (PID2063) -|- C6 (PID2065) -|- C7 (PID2063) -|- C8 (PID2065) -|- Month 1-5 (PID2072) -|- Month 6 (PID2074) -|- Month 7 (PID2061) -|- Month 8-17 (PID2072) -|- Month 18 (PID2074) -|- Month 19 (PID2061) -|- Month 20-30 (PID2072)DA-EPOCH (ETOP50/PRED120/VNCR0.4/CYCL750/DOXO10)/RITU375, B-NHL, C1-2 (PID658) -|- C3-6 (PID2056)DA-EPOCH-R(R), Burkitt's lymphomaGMALL 08/2013-B-ALL/NHL 2002 Regimen, 18 - 55GMALL 08/2013-B-ALL/NHL 2002 regimen, older than 55, B-ALL onlyGMALL 08/2013-B-ALL/NHL 2002 regimen, older than 55, NHL onlyIXAZ4/RITU1400/DEXA20, Waldenström (PID2025) -|- (PID2026) -|- (PID2027) -|- (PID310)MRC/NCRI LY10, Burkitt's LymphomaR-ICE (RITU375/ETOP100/CRBP635/IFOS3), Burkitt's Lymphoma, C1-2 (PID2223) -|- C3 (PID2224).T-ALL: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375, ALL/NHL, C1 (PID2061) -|- C2 (PID2064) -|- C3 (PID2061) -|- C4 (PID2064) -|- C4N (PID2083) -|- C5 (PID2063) -|- C5N (PID2083) -|- C6 (PID2065) -|- C7 (PID2063) -|- C8 (PID2065) -|- Month 1-5 (PID2072) -|- Month 6 (PID2083) -|- Month 7 (PID2083) -|- Month 8-17 (PID2072) -|- Month 18 (PID2074) -|- Month 19 (PID2061) -|- Month 20-30 (PID2072)ChemotherapyChemo-substanceCarboplatinCyclophosphamideCytarabineDexamethasoneDoxorubicinEtoposideFolinic acidIfosfamideImatinibMercaptopurineMethotrexateNaCl 0.9%Peg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceCarboplatinCyclophosphamideCytarabineDexamethasoneDoxorubicinEtoposideFolinic acidIfosfamideImatinibMercaptopurineMethotrexateNaCl 0.9%Peg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceCarboplatinCyclophosphamideCytarabineDexamethasoneDoxorubicinEtoposideFolinic acidIfosfamideImatinibMercaptopurineMethotrexateNaCl 0.9%Peg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceCarboplatinCyclophosphamideCytarabineDexamethasoneDoxorubicinEtoposideFolinic acidIfosfamideImatinibMercaptopurineMethotrexateNaCl 0.9%Peg asparaginasePrednisoloneRituximabVincristineVindesineNo. Substances12345678 RadiotherapySupportive therapySupportive substanceAciclovirAmphotericin BBalanced Crystalloid SolutionCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateSupportive substanceAciclovirAmphotericin BBalanced Crystalloid SolutionCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateSupportive substanceAciclovirAmphotericin BBalanced Crystalloid SolutionCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateSupportive substanceAciclovirAmphotericin BBalanced Crystalloid SolutionCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateNo. Substances12346781014151617Protocol classificationTherapy classificationalternativecurrent standardIntensityDose intensifiedhigh doseStandard doseTherapy indicationFirst lineRelapse therapyTherapy phaseInductionMaintenancePre-phaseReinductionTherapy intentioncurativeRisksAnemia Hb below 8g/dlCardiotoxicityDiarrheaEmetogenicityEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)FatigueFebrile NeutropeniaHypotensionInfectionsMucositisNeuropathyNeutropeniaOral MucositisPyrexiaThrombocytopenia below 50 000/µlTumor Lysis Syndrome only studiesPublicationAuthorDavies ADunleavy KGriffin TCHoelzer DMead GMRausch CRRizzieri DARoschewski MDiseaseBurkitt-Lymphom, ZNS-Befall vor Beginn der TherapieBurkitt-Lymphom bei ErwachsenenBurkitt-Lymphom bei Erwachsenen, ErstlinieErstlinientherapie beim Burkitt-LymphomErstlinientherapie beim primär mediastinalen B-Zell LymphomHochmaligne B-ALL/T-ALL und Burkitt-Lymphom bei Erwachsenen, ErstlinieHochmaligne B-ALL und B-NHL bei Erwachsenen, ErstliniePrimär therapierefraktäres oder rezidiviertes B-NHL oder B-ALL, <21 Jahre, ECOG 0-2OriginCancer Research UK Centre, University of Southampton, UK, SABRINA StudieCenter for Cancer Research, Divison of Cancer Treatment and Diagnosis, National Cancer Institute, BethesdaDivision of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, TexasDuke University Medical Center, Durham, North Carolina, CALGB 9251 trialGerman Multicenter Study Group for Adult Acute Lymphoblastic LeukemiaLymphoid Malignancies Branch, National Cancer Institute, BethesdaMemorial Hospital of South Bend, South BendSouthampton University Hospitals Trust, Southampton, United Kingdom, MRC/NCRI LY10 trialProtocols in Revision 35 protocols foundProtocols under revision.Cyclophosphamide 200 / Prednisolone 60, Pre-phase, Burkitt's lymphoma (PID2214)DA-EPOCH-R - Rituximab 375 / Etoposide 50 / Prednisolone 60 / Vincristine 0.4 / Cyclophosphamide 750 / Doxorubicin 10, B-non-Hodgkin Lymphoma, Cycle 1-2 (PID658)DA-EPOCH-R - Rituximab 375 / Etoposide 72 / Prednisolone 60 / Vincristine 0.4 / Cyclophosphamide 1080 / Doxorubicin 14.4, B-Non-Hodgkin Lymphoma, Cycle 3-6 (PID2056)DA-EPOCH-RR - Rituximab 375 / Etoposide 50 / Prednisolone 60 / Vincristine 0.4 / Cyclophosphamide 750 / Doxorubicin 10, Burkitt lymphoma (PID2222)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part A (PID344)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part B (PID346)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part C (PID347)GMALL 08/2013 - B-ALL/NHL 2002 regimen, all ages, Pre-phase (PID345)GMALL 08/2013 - B-ALL/NHL 2002 regimen, older than 55, part A, NHL only (PID704)GMALL 08/2013 - B-ALL/NHL 2002 regimen, older than 55, part B, NHL only (PID705)GMALL 08/2013 - B-ALL/NHL 2002 regimen, Rituximab consolidation (PID784)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 5 (PID2087)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Ddoxorubicin 50 / Dexamethasone 40) / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 7 (PID2089)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 400, ALL/NHL, Ph/BCR-ABL+, intensification, month 7,19 (PID2113)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 3 (PID2086)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 800, ALL/NHL, Ph/BCR-ABL+, cycle 1 (PID2084)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375, ALL/NHL, cycle 1,3 (PID2061)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40), ALL/NHL, cycle 5,7 (PID2063)Methotrexate 100 / Peg-asparaginase 2000 / Imatinib 400, ALL/NHL, Ph/BCR-ABL+, intensification, month 6,18 (PID2110)Methotrexate 100 / Peg-asparaginase 2000, ALL/NHL, intensification, month 6,18 (PID2074)Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 6 (PID2088)Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 8 (PID2090)Methotrexate 1000 / Cytarabine 3000, ALL/NHL, cycle 6,8 (PID2065)Methotrexate 12, CNS therapy, Burkitt's Lymphoma (PID2231)Methotrexate 15 / Cytarabine 30, Burkitt's Lymphoma (PID2240)POMP (Mercaptopurine 50 / Vincristine 2 / Methotrexate 20 / Prednisolone 200), ALL/NHL, maintenance, month 1-5,8-17,20-30 (PID2072)R-ICE - Rituximab 375 / Etoposide 100 / Carboplatin 5 / Ifosfamide 3, Burkitt's Lymphoma, Cycle 1-2. (PID2223)R-ICE - Rituximab 375 / Etoposide 100 / Carboplatin 5 / Ifosfamide 3, Burkitt's Lymphoma, Cycle 3. (PID2224)R-IVAC - Cytarabine 2000 / Rituximab 375 / Etoposide 60 / Ifosfamide 1.5, Burkitt's lymphoma (PID2212)R-modified CODOX-M - Rituximab 375 / Cyclophosphamide (800/200) / Vincristine 2 / Doxorubicin 40 / Methotrexate 3000, Burkitt lymphoma (PID2211)Rituximab 1400, single dose subcutaneous (PID310)Rituximab 375 / Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 2,4 (PID2085)Rituximab 375 / Methotrexate 1000 / Cytarabine 3000, ALL/NHL, cycle 2,4 (PID2064)Rituximab 375, Burkitt's lymphoma (PID2218)Vincristine 2 / Prednisolone 200 / Imatinib 400, ALL/NHL, maintenance, Ph/BCR-ABL+ (PID2073)
