Search Back New search Go to resultsDiseaseMain groupSolid TumorsProtocol groupGynecological OncologyNeuro-OncologyDiseaseChorionic CarcinomaGestational Trophoblastic NeoplasiaMalignant MeningitisSubgroupICD10C58C79.3D39.-D39.2MeSHChoriocarcinomaGestational Trophoblastic DiseaseMeningeal CarcinomatosisSequenceCISP20/ETOP100, GTN, Ind. (PID1608) -|- EMA/CO (ETOP100/DCTN0.5/MTRX1000/VNCR1.0/CYCL600) (PID1610) or (PID1607) with (PID1616)ChemotherapyChemo-substanceAvelumabCisplatinCyclophosphamideDactinomycinEtoposideFolinic acidMethotrexatePaclitaxelPembrolizumabVincristineChemo-substanceAvelumabCisplatinCyclophosphamideDactinomycinEtoposideFolinic acidMethotrexatePaclitaxelPembrolizumabVincristineChemo-substanceAvelumabCisplatinCyclophosphamideDactinomycinEtoposideFolinic acidMethotrexatePaclitaxelPembrolizumabVincristineChemo-substanceAvelumabCisplatinCyclophosphamideDactinomycinEtoposideFolinic acidMethotrexatePaclitaxelPembrolizumabVincristineNo. Substances12345 RadiotherapySupportive therapySupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDextrose 5%DimetindenFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMagnesium sulfateMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chlorideSodium BicarbonateSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDextrose 5%DimetindenFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMagnesium sulfateMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chlorideSodium BicarbonateSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDextrose 5%DimetindenFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMagnesium sulfateMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chlorideSodium BicarbonateSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDextrose 5%DimetindenFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMagnesium sulfateMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chlorideSodium BicarbonateNo. Substances1346912Protocol classificationTherapy classificationalternativecurrent standardIntensityLow doseStandard doseTherapy indicationFirst lineRefractory diseaseseveral possibleTherapy phaseInductionTherapy intentioncurativeRisksAnemia Hb below 8g/dlAnemia Hb below 10g/dlAstheniaColitisDiarrheaDyspneaEmetogenicityEmetogenicity (MASCC/ESMO)Febrile NeutropeniaHemorrhageHepatotoxicityHyperthyroidismHypothyroidismInfectionsInfusion ReactionLeukopeniaMucositisNephritisNeuropathyNeutropeniaOral MucositisPneumonitisProteinuriaRenal FailureThrombocytopenia below 50 000/µl only studiesPublicationAuthorAlifrangis CGhorani EMao YMcNeish IAOsborne RJWang JYou BDiseaseGestationale trophoblastäre Neoplasie, rezidiviert oder refraktär nach Therapie mit EMA/COtherapieresistente gestationale trophoblastäre NeoplasieTrophoblastäre gestationale Neoplasie, chemotherapieresistent, ECOG 0-2Trophoblastäre gestationale Neoplasie, high-risk (FIGO score 7 oder höher)Trophoblastäre gestationale Neoplasie, high-risk (FIGO score über 12)Trophoblastäre gestationale Neoplasie, low riskTrophoblastäre gestationale Neoplasie, rezidiviert oder therapierefraktärTrophoblastäre gestationale Neoplasie und nichtmetastasiertes ChorionkarzinomOriginCentre de Reference des Maladies Trophoblastiques, Lyon, France, TROPHIMMUNCharing Cross Hospital, Imperial College London, UKImperial College Academic Science National Health Service Trust, London, United KingdomThe Gynecologic Oncology GroupThe Trophoblastic Tumour Screenig and Treatment CenterZhejiang University, Hangzhou, ChinaProtocols in Revision 10 protocols foundProtocols under revision.Avelumab 800, Gestational Trophoblastic Neoplasia (PID1612 V1.1)Cisplatin 20 / Etoposide 100, Gestational Trophoblastic Neoplasia, induction (PID1608 V1.1)Dactinomycin 1,25, Gestational Trophoblastic Neoplasia (PID95 V1.0)EMA/CO (Etoposide 100 / Dactinomycin 0.5 / Methotrexate 1000 / Vincristine 1.0 / Cyclophosphamide 600), Gestational Trophoblastic Neoplasia with Brain Metastases (PID1610 V1.2)EMA/CO (Etoposide 100 / Dactinomycin 0.5 / Methotrexate 300 / Vincristine 1.0 / Cyclophosphamide 600), Gestational Trophoblastic Neoplasia (PID1607 V1.2)EP/EMA - Etoposide 150 / Cisplatin 75 / Etoposide 100 / Methotrexate 300 / Dactinomycin 0.5, Gestational Trophoblastic Neoplasia. (PID1611 V1.3)Methotrexate 12.5, Gestational Trophoblastic Neoplasia (PID1616 V1.1)Methotrexate 50, i.m., Gestational Trophoblastic Neoplasia (PID564 V1.0)Pembrolizumab 200, Gestational Trophoblastic Neoplasia (PID1536 V1.0)TP-TE (Paclitaxel 135 / Cisplatin 60 - Paclitaxel 135 / Etoposide 150), Gestational Trophoblastic Neoplasia (PID1609 V1.1)
