Search Back New search Go to resultsDiseaseMain groupSolid TumorsProtocol groupGynecological OncologyNeuro-OncologyDiseaseBreast CancerGestational Trophoblastic NeoplasiaMalignant MeningitisSubgroupHER2+ICD10C50.-C79.3D39.-D39.2MeSHBreast NeoplasmsGestational Trophoblastic DiseaseMeningeal CarcinomatosisSequenceCISP20/ETOP100, GTN, Ind. (PID1608) -|- EMA/CO (ETOP100/DCTN0.5/MTRX1000/VNCR1.0/CYCL600) (PID1610) or (PID1607) with (PID1616)TRAS80, Malignant Meningitis, C1 (PID2526) -|- C2 (PID2527) -|- C3+ (PID2542)ChemotherapyChemo-substanceMethotrexateTopotecanTrastuzumabChemo-substanceMethotrexateTopotecanTrastuzumabChemo-substanceMethotrexateTopotecanTrastuzumabChemo-substanceMethotrexateTopotecanTrastuzumabNo. Substances1 RadiotherapySupportive therapySupportive substanceDexamethasoneFolinic acidGranisetronPrednisoloneSupportive substanceDexamethasoneFolinic acidGranisetronPrednisoloneSupportive substanceDexamethasoneFolinic acidGranisetronPrednisoloneSupportive substanceDexamethasoneFolinic acidGranisetronPrednisoloneNo. Substances12Protocol classificationTherapy classificationalternativecurrent standardIntensityStandard doseTherapy indicationseveral possibleTherapy phaseInductionMaintenanceTherapy intentioncurativepalliativeRisksAllergic ReactionAnemia Hb below 10g/dlArachnoiditisDiarrheaEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)Febrile NeutropeniaHeadacheHepatotoxicityLeukopeniaMucositisNauseaNeuropathySeizuresThrombocytopenia below 50 000/µlVomiting only studiesPublicationAuthorAlifrangis CGroves MKumthekar POberkampf FDiseaseLeptomeningeale Metastasen beim Mamma-Ca, HER2+, ECOG 0-3Leptomeningeale Metastasen beim Mamma-Ca, HER2+, Karnofsky >50Refraktäre Meningeosis neoplastica, Erstlinie für Meningeosis neoplastica, Karnofsky > 60Trophoblastäre gestationale Neoplasie, high-risk (FIGO score 7 oder höher)OriginDepartment of Neurology at The Feinberg School of Medicine at Northwestern University, USDepartment of Oncology, Institut Curie-St Cloud, FranceImperial College Academic Science National Health Service Trust, London, United KingdomUniversity of Texas M. D. Anderson Cancer Center, Houston, TXProtocols in Revision 6 protocols foundProtocols under revision.Methotrexate 12.5, Gestational Trophoblastic Neoplasia (PID1616 V1.1)Topotecan 0.4, Malignant Meningitis (PID2520 V1.0)Trastuzumab 150, Malignant Meningitis (PID2523 V1.0)Trastuzumab 80, Malignant Meningitis, Cycle 1 (PID2526 V1.0)Trastuzumab 80, Malignant Meningitis, Cycle 2 (PID2527 V1.0)Trastuzumab 80, Malignant Meningitis, Cycle 3+ (PID2542 V1.0)
