Search Protocols under revision. Back New search Go to resultsDiseaseMain groupSolid TumorsProtocol groupEndocrine and Neuroendocrine OncologyUrologic OncologyDiseaseNeuroendocrine CarcinomaProstate CancerSubgroupATM-MutationBRCA mutationcastration resistantDNA Repair Defecthormone sensitiveneuroendocrinePTEN-deficientsmall cellICD10C61C80.9MeSHCarcinoma, NeuroendocrineProstatic DiseasesProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantSequenceARASENS: DOCE75/DARO600/GOSE10.8, Prostate Ca (HS), C1 (PID2040) -|- C2 (PID2041) -|- Maint. (PID2081)DGRL240, Prostate Ca, C1 (PID1524) -|- DGRL80, C2+ (PID1525)DOCE75/PRED5/GOSE10.8, Prostate Ca (HS), C1 (PID641) -|- DOCE75/PRED5/GOSE10.8, C2 (PID664) -|- GOSE10.8, maint. (PID2082)ENZAMET: ENZA160/GOSE10.8/DOCE75, Prostate Ca (HS), C1 (PID2806) -|- C2 (PID3073) -|- Maint. (PID3074)HERO: RELU(360/120), Prostate Ca, C1 (PID2250) -|- RELU120, C2+ (PID2247).PEACE-1: DOCE75/PRED5/ABIR1000/GOSE10.8, Prostate Ca (HS), A (PID2305) -|- B (PID2306) -|- C (PID2307).PEMB200/CISP75/ETOP100, Prostate Ca, C1-6 (PID2783) -|- PEMB200, C7-35 (PID2784)PEMB200/CRBP5/ETOP100, Prostate Ca, C1-6 (PID2785) -|- PEMB200, C7-35 (PID2784)PEMB200/DOCE60/CRBP5, Prostate Ca, C1-6 (PID2786) -|- PEMB200, C7-35 (PID2784)Antineoplastic therapySubstanceAbirateroneApalutamideBicalutamideBuserelinCabazitaxelCapivasertibCarboplatinCisplatinDarolutamideDegarelixDexamethasoneDocetaxelEnzalutamideEtoposideGoserelinLeuprorelinMitoxantroneNiraparibOlaparibPembrolizumabPrednisoloneRelugolixRucaparibTalazoparibTriptorelinSubstanceAbirateroneApalutamideBicalutamideBuserelinCabazitaxelCapivasertibCarboplatinCisplatinDarolutamideDegarelixDexamethasoneDocetaxelEnzalutamideEtoposideGoserelinLeuprorelinMitoxantroneNiraparibOlaparibPembrolizumabPrednisoloneRelugolixRucaparibTalazoparibTriptorelinSubstanceAbirateroneApalutamideBicalutamideBuserelinCabazitaxelCapivasertibCarboplatinCisplatinDarolutamideDegarelixDexamethasoneDocetaxelEnzalutamideEtoposideGoserelinLeuprorelinMitoxantroneNiraparibOlaparibPembrolizumabPrednisoloneRelugolixRucaparibTalazoparibTriptorelinSubstanceAbirateroneApalutamideBicalutamideBuserelinCabazitaxelCapivasertibCarboplatinCisplatinDarolutamideDegarelixDexamethasoneDocetaxelEnzalutamideEtoposideGoserelinLeuprorelinMitoxantroneNiraparibOlaparibPembrolizumabPrednisoloneRelugolixRucaparibTalazoparibTriptorelinAnzahl Substanzen1234 RadiotherapySupportive therapySubstanceBalanced Crystalloid SolutionDexamethasoneDimetindenFamotidineFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSubstanceBalanced Crystalloid SolutionDexamethasoneDimetindenFamotidineFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSubstanceBalanced Crystalloid SolutionDexamethasoneDimetindenFamotidineFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSubstanceBalanced Crystalloid SolutionDexamethasoneDimetindenFamotidineFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideAnzahl Substanzen123457Protocol classificationTherapy classificationalternativecurrent standardIntensityStandard doseTherapy indicationFirst lineSecond lineseveral possibleTherapy phaseInductionMaintenanceTherapy intentioncurative or palliativedisease controlpalliativeRisksAllergic ReactionAlopeciaAnemia Hb below 8g/dlArthalgiaAstheniaBone PainCardiotoxicityConstipationDepressionDiarrheaDyspneaEdemaEmetogenicityEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)FatigueFebrile NeutropeniaFractureGynecomastiaHeadacheHeart FailureHematuriaHepatotoxicityHypercholesterolemiaHyperglycemiaHyperhidrosisHyperkalemiaHypertensionHypokalemiaHypotensionHypothyroidismIncrease Alkaline PhosphataseIncrease AminotransferasesInfectionsLeukopeniaLibido ReductionMuscle WeaknessNauseaNeuropathyNeutropeniaOral MucositisOsteopeniaPainParesthesiaPneumoniaQTc Time ExtensionRashRenal FailureSepsisSpinal Cord CompressionThrombocytopenia below 50 000/µlThromboembolic EventVomiting only studiesPublicationAuthorAgarwal NApostolidis LBeer TBolton EMChi KChi KNClarke NWCorn PG Davis IDDe Bono Jde Bono Jde Bono JSEisenberger MFizazi KGu WGu YHellmann MDKellokumpu-Lehtinen PKlotz LOudard SRomero-Laorden NRyan CScher HShore NDSmith MRSternberg CNSweeney JCTannock ITannock IFDiseaseFortgeschrittenes hormonsensitives ProstatakarzinomFortgeschrittenes oder metastasiertes Prostata-Ca, kastrationsresistent, ECOG 0-2Fortgeschrittenes Prostatakarzinomkastrationsresistentes Prostatakarzinom, Progress nach Docetaxel, Testosteron < 50 ng/dl, ECOG 0-2metastasiertes, hormonresistentes Prostata-Ca, Serumtestosteron < 50 ng/dl, Karnofsky > 60Metastasiertes, hormonresistentes Prostata-Ca, Serumtestosteron < 50 ng/dl, Karnofsky > 60Metastasiertes, hormonsensitives Prostata-Ca, Serumtestosteron < 50 ng/dl, ECOG 0-2metastasiertes, hormonsensitives Prostata-Ca, Serumtestosteron < 50 ng/dl, ECOG 0-2Metastasiertes, hormonsensitives Prostata KarzinomMetastasiertes, hormonsensitives Prostatakarzinommetastasiertes, hormonsensitives Prostata KarzinomMetastasiertes, kastrationsresistentes Prostata-Ca, Progress unter Abirateron/Prednisolon, Serumtestosteron < 50 ng/dl, ECOG 0-1metastasiertes, kastrationsresistentes Prostata-Ca, Serumtestosteron < 50 ng/dl, ECOG 0-1metastasiertes, kastrationsresistentes Prostata-Ca, symptomatisch, ECOG 0-3metastasiertes, kastrationsresistentes Prostata-Ca mit BRCA1, BRCA2, oder ATM Mutation, Progress nach Androgenrezeptor-Antagonisten der 2. GenerationMetastasiertes, kastrationsresistentes Prostatakarzinom, asymptomatisch oder wenig Symptome, ECOG 0-1metastasiertes, kastrationsresistentes Prostatakarzinom, Progress nach Docetaxel, Testosteron < 50 ng/dl, ECOG 0-2Metastasiertes, kastrationsresistentes Proststa Karzinom nach Docetaxel Therapie, ECOG 0-2Metastasiertes hormonsensitives Prostatakarzinom, ECOG 0-1Metastasiertes hormonsensitives Prostatakarzinom, ECOG 0-2, mindestens 2 von 3 Kriterien positiv: Gleason Score gleich oder höher 8; 3 oder mehr Knochenmetastasen; viszerale Metastasen.Metastasiertes kastrationsresistentes Prostata-Ca, ErstlinieMetastasiertes kastrationsresistentes Prostata-Ca, Erstlinie, HRR+Metastasiertes kastrationsresistentes Prostata-Ca, progredient nach Therapie mit z.B. Enzalutamid oder AbirateronMetastasiertes kastrationsresistentes Prostatakarzinom, 65 J. oder älter, nach Therapie mit Docetaxel, ECOG 0-2Metastasiertes kastrationsresistentes Prostatakarzinom, ECOG 0-2Metastasiertes kastrationsresistentes Prostatakarzinom, Erstlinie, ECOG 0-2metastasiertes kastrationsresistentes Prostatakarzinom, Erstlinie, ECOG 0-2Metastasiertes Prostatakarzinom, mind. 4 ossäre Metastasen, ECOG 0-1Neudiagnostiziertes Prostatakarzinom, metastasiert, hormonsensitiv, ECOG 0-2Neuroendokrines / Kleinzelliges ProstatakarzinomNeuroendokrines Prostatakarzinom, Erst- und Zweitlinienicht metastasiertes, kastrationsresistentes Hochrisiko Prostata-Canicht metastasiertes, kastrationsresistentes Prostata-Ca, ECOG 0-1nicht metastasiertes, kastrationsresistentes Prostata-Ca, PSA-Verdopplungszeit weniger als 10 Monate, ECOG 0-1Prostatakarzinom, alle Stadien, ECOG 0-2Prostatakarzinom, lokal fortgeschritten oder metastasiert, hormonsensitiv, PTEN defizient, ECOG 0-1Originassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, ARASENS trialCarolina Urologic Research Center, Myrtle Beach, SC, HERO trialDepartment of Cancer Medicine, Institut Gustave Roussy, Centre Oscar Lambret, University of Paris Saclay, Villejuif, France, CAPItello-281 trialDepartment of Medical Oncology, University Hospital HeidelbergDepartment of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, TAX 327 InvestigatorsDepartment of Medicine and the Department of Biostatics and Computational Biology, Dana Farber Cancer Institute, BostonDepartment of Oncology, Tampere University Hospital, Tampere, Finland, PROSTY study groupDepartment of Urology, St James's Hospital, Dublin, IrelandDepartment of Urology, St James Hospital, Dublin, IrelandEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, USA, PROSPER trialFudan University Shanghai Cancer Center, Shanghai, China, CHART trialGenitourinary Medical Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, COU-AA-302 InvestigatorsGeorge Pompidou European Hosptial, Paris, FIRSTANAGustave Roussy, University of Paris Sud, Villejuif, France, LATITUDE trialGustave Roussy Institute, Paris-Saclay University, Villejuif, France, TRITON3 trialHopital European Georges-Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP), University Paris Cite, Paris, France, CABASTY trialHuntsman Cancer Institute (NCI-CCC), University of Utah, Salt Lake City, UT, USA, TALAPRO-2 trialInstitute of Cancer Research and Royal Marsden Hospital, Sutton, COU-AA-301 InvestigatorsInstitute of Cancer Research and Royal Marsden Hospital, Sutton, United Kingdom, PROfound trialInstitut Gustave Roussy, Universite Paris-Sud, Villejuif, France, ARAMIS trialInstitut Gustave Roussy, University of Paris-Saclay, Villejuif, France, PEACE-1Massachusetts General Hospital Cancer Center, BostonMassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, ARASENS trialMemorial Sloan-Kettering Cancer Center, New York, AFFIRM trialMonash University, Australia, ENZAMET TRIALOHSU Knight Cancer Institute, Oregon Health and Science University, PREVAIL trialPrincess Margaret Hospital, Toronto, CanadaRoyal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK, TROPICSpanish National Cancer Research Centre (CNIO), Madrid, Spain, SWITCH trialThe Johns Hopkins University, Baltimore, PROSELICAUniversity of British Columbia, CancerdVancouver Center, Vancouver, Canada, MAGNITUDE trialUniversity of California, Los Angeles, Los Angeles, CA, USAUniversity of Manchester, Manchester, United Kingdom, PROpel trialUniversity of Paris Sud, Villejuif, France, LATITUDE StudieUniversity of Texas MD Anderson Cancer Center, Houston, USAUniversity of Toronto, CanadaVancouver Prostate Centre, Vancouver, Canada, TITANProtocols in Revision 53 protocols foundAbiraterone 1000 / Dexamethasone 0.5, Prostate Cancer Castration Resistant (PID2311 V1.0)Abiraterone 1000 / Prednisolone 5 / Goserelin 10.8, Prostate Cancer hormone sensitive (PID1002 V1.2)Abiraterone 1000 / Prednisolone 5, Prostate Cancer Hormone Sensitive (PID1504 V1.2)Abiraterone 1000 / Prednisolone 5, Prostate Cancer, First Line (PID919 V1.1)Abiraterone 1000 / Prednisolone 5, Prostate Cancer, Second Line (PID920 V1.1)Apalutamide 240, Prostate Cancer hormone sensitive (PID1503 V1.0)Apalutamide 240, Prostate Cancer Castration Resistant (PID1232 V1.1)Bicalutamide 50 / Goserelin 10.8, Prostate Cancer (PID3076 V1.0)Buserelin 9.45, Prostate Cancer (PID1523 V2.0)Cabazitaxel 16 / Prednisolone 10, Prostate Cancer (PID3075 V1.0)Cabazitaxel 20 / Prednisolone 10, Prostate Cancer, First Line (PID1129 V1.1)Cabazitaxel 20 / Prednisolone 10, Prostate Cancer, Second Line (PID1134 V1.1)Cabazitaxel 25 / Carboplatin 4 / Prednisolone 5 Prostate Cancer (PID2310 V1.0)Cabazitaxel 25 / Prednisolone 10, Prostate Cancer, First Line (PID1104 V1.1)Cabazitaxel 25 / Prednisolone 10, Prostate Cancer, Second Line (PID645 V1.1)Capivasertib 400 / Abiraterone 1000 / Prednisolone 5, Prostate Cancer (PID3052 V1.0)Cisplatin 25 / Etoposide 100, Neuroendocrine Prostate Cancer (PID1283 V1.1)Darolutamide 600, Prostate Cancer Castration Resistant (PID1642 V1.0)Degarelix 240, Prostate Cancer, Cycle 1 (PID1524 V1.0)Degarelix 80, Prostate Cancer, Cycle 2+ (PID1525 V1.0)Docetaxel 30 / Prednisolone 5, Prostate Cancer (PID1391 V1.1)Docetaxel 50 / Prednisolone 5, Prostate Cancer castration-resistant (PID941 V1.2)Docetaxel 75 / Darolutamide 600 / Goserelin 10.8 - Darolutamide 600 / Goserelin 10.8, Prostate Cancer hormone-sensitive, maintenance (PID2081 V1.1)Docetaxel 75 / Darolutamide 600 / Goserelin 10.8, Prostate Cancer hormone sensitive, cycle 1 (PID2040 V1.2)Docetaxel 75 / Darolutamide 600 / Goserelin 10.8, Prostate Cancer hormone sensitive, cycle 2 (PID2041 V1.2)Docetaxel 75 / Goserelin 10.8 - Goserelin 10.8, Prostate Cancer hormone-sensitive, maintenance (PID2082 V1.3)Docetaxel 75 / Goserelin 10.8, Prostate Cancer hormone sensitive, cycle 1 (PID641 V2.1)Docetaxel 75 / Goserelin 10.8, Prostate Cancer hormone sensitive, cycle 2 (PID664 V2.1)Docetaxel 75 / Prednisolone 5 / Abiraterone 1000 / Goserelin 10.8 - Abiraterone 1000 / Goserelin 10.8, Prostate Cancer hormone-sensitive, part C (PID2307 V1.1)Docetaxel 75 / Prednisolone 5 / Abiraterone 1000 / Goserelin 10.8, Prostate Cancer hormone-sensitive, cycle 1 (PID2305 V1.1)Docetaxel 75 / Prednisolone 5 / Abiraterone 1000 / Goserelin 10.8, Prostate Cancer hormone-sensitive, cycle 2 (PID2306 V1.1)Docetaxel 75 / Prednisolone 5, Prostate Cancer (PID921 V1.1)Enzalutamide 160 / Goserelin 10.8 / Docetaxel 75 - Enzalutamide 160 / Goserelin 10.8, Prostate Cancer hormone-sensitive, maintenance (PID3074 V1.0)Enzalutamide 160 / Goserelin 10.8 / Docetaxel 75, Prostate Cancer hormone sensitive, cycle 2 (PID3073 V1.0)Enzalutamide 160 / Goserelin 10.8, Prostate Cancer hormone sensitive (PID1360 V2.1)Enzalutamide 160, Prostate Cancer Castration Resistant (PID1557 V1.0)Enzalutamide 160, Prostate Cancer castration-resistant, first-line (PID918 V1.0)Enzalutamide 160, Prostate Cancer castration-resistant, second-line (PID917 V1.0)Goserelin 10.8, Prostate Cancer (PID1520 V1.0)Leuprorelin 11.25, Prostate Cancer (PID1521 V1.0)Mitoxantrone 12 / Prednisolone 5, Prostate Cancer castration resistant (PID2309 V1.0)Niraparib 200 / Abiraterone 1000 / Prednisolone 5, Prostate Cancer castration-resistant (PID2557 V1.1)Olaparib 300 / Abiraterone 1000 / Prednisolone 5, Prostate Cancer castration resistant (PID2326 V1.0)Olaparib 300, Prostate Cancer Castration Resistant (PID1559 V1.0)Pembrolizumab 200 / Carboplatin 5 / Etoposide 100, Prostate Cancer, Cycle 1-6 (PID2785 V1.0)Pembrolizumab 200 / Cisplatin 75 / Etoposide 100, Prostate Cancer, Cycle 1-6 (PID2783 V1.0)Pembrolizumab 200 / Docetaxel 60 / Carboplatin 5, Prostate Cancer, Cycle 1-6 (PID2786 V1.0)Pembrolizumab 200, Prostate Cancer, Cycle 7-35 (PID2784 V1.0)Relugolix (360/120), Prostate Cancer, Cycle 1 (PID2250 V1.0)Relugolix 120, Prostate Cancer, Cycle 2+ (PID2247 V1.0)Rucaparib 600, Prostate Cancer Castration Resistant (PID2308 V1.0)Talazoparib 0.5 / Enzalutamide 160, Prostate Cancer castration-resistant (PID2556 V1.0)Triptorelin 11,25, Prostate Cancer (PID1522 V1.0)
