Search Back New search Go to resultsDiseaseMain groupCross-Sectional, Transplantation, Cellular TherapySolid TumorsProtocol groupGastroenterologic OncologyradiotherapyDiseaseAnal CarcinomaSubgroupPD-L1+unfitICD10C21.-C21.0C21.1C21.2C21.8MeSHAnus NeoplasmsSequencePOD1UM-303/InterAACT 2: CRBP5/PACL80/RETI500, Anal-Ca (PID2868) -|- RETI500, Maint. (PID2869)ChemotherapyChemo-substanceCapecitabineCarboplatinCisplatinDocetaxelFluorouracilFolinic acidMitomycinNivolumabPaclitaxelPembrolizumabRetifanlimabChemo-substanceCapecitabineCarboplatinCisplatinDocetaxelFluorouracilFolinic acidMitomycinNivolumabPaclitaxelPembrolizumabRetifanlimabChemo-substanceCapecitabineCarboplatinCisplatinDocetaxelFluorouracilFolinic acidMitomycinNivolumabPaclitaxelPembrolizumabRetifanlimabChemo-substanceCapecitabineCarboplatinCisplatinDocetaxelFluorouracilFolinic acidMitomycinNivolumabPaclitaxelPembrolizumabRetifanlimabNo. Substances123 RadiotherapySupportive therapySupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDimetindenFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDimetindenFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDimetindenFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideSupportive substanceBalanced Crystalloid SolutionCimetidineDexamethasoneDimetindenFosaprepitantGranisetronMagnesiumMagnesium sulfatePegfilgrastimPotassium chlorideNo. Substances1267Protocol classificationTherapy classificationalternativecurrent standardstudy analogIntensityStandard doseTherapy indicationFirst lineSecond lineseveral possibleTherapy phaseInductionMaintenanceTherapy intentioncurativepalliativeRisksAdrenal InsufficiencyAnemia Hb below 8g/dlArthalgiaAstheniaCardiotoxicityColitisConstipationDehydrationDiarrheaEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)FatigueFebrile NeutropeniaHand-Foot SyndromeHyperglycemiaHyperkalemiaHyperthyroidismHypothyroidismInfectionsLeukopeniaMucositisNeuropathyNeutropeniaOtotoxicityPneumonitisPruritusRadiation DermatitisRashRenal FailureThrombocytopenia below 50 000/µlThromboembolic Event only studiesPublicationAuthorAjani JAKim SMondaca SMorris VKOtt PARao SThind GXu WDDiseaseAnalkarzinom, cM0, Karnofsky 70-100%Analkarzinom, metastasiert oder lokal fortgeschritten, inoperabelAnalkarzinom, Plattenepithel-, metastasiert oder nichtresezierbares Rezidiv, ECOG 0-1 Analkarzinom, rezidiviert oder metastasiert, ECOG 0-1lokal fortgeschrittenes, nicht operables oder metastasiertes Analkarzinom, PD-L1+, Zweitlinientherapie, ECOG 0-1lokal fortgeschrittenes, nicht operables oder metastasiertes Analkarzinom, Zweitlinientherapie, ECOG 0-1Metastasiertes oder fortgeschrittenes Anal-Ca, nichtresezierbar, ECOG 0-1Plattenepithel- , Basalzell- oder kloakogenes Anal-Ca, T2-T4, jedes N, M0Plattenepithel- oder kloakogenes Anal-Ca, Stadium I-III, ECOG 0-2wiederkehrendes oder metastasiertes, nicht resezierbares Analkarzinom, ECOG 0-1OriginCenter for Immuno-Oncology, Dana-Farber Cancer Institute, BostonDepart. of Gastroint. Med. Oncology, Anderson Cancer Center, Texas, USA. Intergroup RTOG 98-11 StudieDepartment of Oncology, University Hospital of Besancon, Besançon, FranceDepartment of Radiation Oncology, The Seventh Medical Center of PLA General Hospital, Beijing, ChinaGI and Lymphoma Unit, Royal Marsden Hospital NHS Foundation Trust, Surrey, UK, POD1UM-303/InterAACT 2Memorial Sloan Kettering Cancer CenterRoyal Marsden Hospital, London, United Kingdom, INTERAACT trialThe British Columbia Cancer AgencyThe Royal Marsden, London, UK, POD1UM-202 trialThe University of Texas, MD Anderson Cancer Center, Houston, USA, NCI9673Protocols in Revision 12 protocols foundProtocols under revision.Capecitabine 625 / Radiation, Anal Carcinoma (PID2754 V1.0)Capecitabine 825 / Mitomycin 12 / Radiation, Anal Carcinoma (PID481 V1.1)Carboplatin 5 / Paclitaxel 80 / Retifanlimab 500 - Retifanlimab 500, Anal Carcinoma, maintenance (PID2869 V1.0)Carboplatin 5 / Paclitaxel 80 / Retifanlimab 500, Anal Carcinoma (PID2868 V1.0)Cisplatin 40 / Folinic Acid 400 / Fluorouracil 1000, Anal Carcinoma (PID1978 V1.1)Fluorouracil 1000 / Cisplatin 100, Anal Carcinoma (PID482 V1.1)Fluorouracil 1000 / Mitomycin 10 / Radiation, Anal Carcinoma (PID480 V1.1)modified Docetaxel 40 / Cisplatin 40 / Fluorouracil 1200, Anal Carcinoma (PID628 V1.2)Nivolumab 240, Anal Carcinoma (PID1749 V1.0)Paclitaxel 80 / Carboplatin 5, Anal Carcinoma (PID1352 V1.3)Pembrolizumab 200, Anal Carcinoma (PID1750 V1.0)Retifanlimab 500, Anal Carcinoma (PID2867 V1.0)
