Search Back New search Go to resultsDiseaseMain groupHematologic NeoplasmsProtocol groupAcute LeukemiasAggressive LymphomasIndolent LymphomasT-Cell and NK-Cell NeoplasmsDiseaseAcute Lymphoblastic LeukaemiaChronic Lymphocytic Leukemia / Small Lymphocytic LymphomaMalignant MeningitisMantle Cell LymphomaNHL, B-Cell Type, Anaplastic Large Cell Lymphoma, ALK-PositiveNHL, B-Cell Type, Burkitt's LymphomaNHL, B-Cell Type, Diffuse Large CellNHL, B-Cell Type, Follicular Grade I-IIIaNHL, B-Cell Type, Follicular grade IIIbNHL, B-Cell Type, IndolentNHL, B-Cell Type, Lymphoblastic LymphomaNHL, T-Cell Type, Adult T-Cell Leukemia or LymphomaNHL, T-Cell Type, Lymphoblastic LymphomaSubgroupB-ALLPh/BCR-ABL+Ph/BCR-ABL-T-ALLICD10C79.3C82.-C82.7C82.9C83.1C83.3C83.5C83.7C84.6C91.0-C91.1-C91.5-MeSHBurkitt LymphomaLymphoma, Mantle-CellMeningeal CarcinomatosisPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaSequenceALL, Mini-hyperCVD/Inotuzumab Ozogamicin: Mini-hyperCVD (CYCL150/VNCR2/DEXA20)/INTZ(0.6/0.3)/RITU375, ALL/NHL, C1 (PID2098) -|- C2 (PID2097) -|- C3 (PID2099) -|- C4 (PID2097) -|- maint. (PID313)ALL,Ph/BCR-ABL+: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375/IMAT800, ALL/NHL, Ph/BCR-ABL+, C1 (PID2084) -|- C2 (PID2085) -|- C3 (PID2086) -|-C4 (PID2085) -|- C5 (PID2087) -|- C6 (PID2088) -|- C7 (PID2089) -|- C8 (PID2090) -|- Month 1-5 (PID2073) -|- Month 6 (PID2110) -|- Month 7 (PID2113) -|- Month 8-17 (PID2073) -|- Month 18 (PID2110) -|- Month 19 (PID2113) -|- Month 20-24 (PID2073)B-ALL/recurrent therapy: mini-hyperCVD (CYCL150/VNCR2/DEXA20)/INTZ(0.6/0.3)/RITU375, ALL/NHL, C1 (PID2098) -|- C2 (PID2097) -|- C3 (PID2099) -|- C4 (PID2097) -|- C1 (PID2117) -|- C2-4 (PID2118) -|- maint., Month 1-12 (PID2119) -|- maint., month 13-36 (PID2120)B-ALL: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375, B-ALL/NHL, C1 (PID2061) -|- C2 (PID2064) -|- C3 (PID2061) -|- C4 (PID2064) -|- C5 (PID2063) -|- C6 (PID2065) -|- C7 (PID2063) -|- C8 (PID2065) -|- Month 1-5 (PID2072) -|- Month 6 (PID2074) -|- Month 7 (PID2061) -|- Month 8-17 (PID2072) -|- Month 18 (PID2074) -|- Month 19 (PID2061) -|- Month 20-30 (PID2072)GMALL 08/2013-ALL/LBL, 56 - 75GMALL 08/2013-ALL/LBL, 56 - 75, Ph/BCR-ABL+GMALL 08/2013-ALL/LBL 18 - 55GMALL 08/2013-ALL/LBL 18 - 55, Ph/BCR-ABL+GMALL 08/2013-B-ALL/NHL 2002 Regimen, 18 - 55GMALL 08/2013-B-ALL/NHL 2002 regimen, older than 55, B-ALL onlyGMALL 08/2013-B-ALL/NHL 2002 regimen, older than 55, NHL onlyIXAZ4/RITU1400/DEXA20, Waldenström (PID2025) -|- (PID2026) -|- (PID2027) -|- (PID310)R-ICE (RITU375/ETOP100/CRBP635/IFOS3), Burkitt's Lymphoma, C1-2 (PID2223) -|- C3 (PID2224).T-ALL: Hyper-CVAD (CYCL300/VNCR2/DOXO50/DEXA40)/RITU375, ALL/NHL, C1 (PID2061) -|- C2 (PID2064) -|- C3 (PID2061) -|- C4 (PID2064) -|- C4N (PID2083) -|- C5 (PID2063) -|- C5N (PID2083) -|- C6 (PID2065) -|- C7 (PID2063) -|- C8 (PID2065) -|- Month 1-5 (PID2072) -|- Month 6 (PID2083) -|- Month 7 (PID2083) -|- Month 8-17 (PID2072) -|- Month 18 (PID2074) -|- Month 19 (PID2061) -|- Month 20-30 (PID2072)ChemotherapyChemo-substanceBlinatumomabCarboplatinCyclophosphamideCytarabineDaunorubicinDexamethasoneDoxorubicinEtoposideIdarubicinIfosfamideImatinibInotuzumab OzogamicinMercaptopurineMethotrexateNelarabinePeg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceBlinatumomabCarboplatinCyclophosphamideCytarabineDaunorubicinDexamethasoneDoxorubicinEtoposideIdarubicinIfosfamideImatinibInotuzumab OzogamicinMercaptopurineMethotrexateNelarabinePeg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceBlinatumomabCarboplatinCyclophosphamideCytarabineDaunorubicinDexamethasoneDoxorubicinEtoposideIdarubicinIfosfamideImatinibInotuzumab OzogamicinMercaptopurineMethotrexateNelarabinePeg asparaginasePrednisoloneRituximabVincristineVindesineChemo-substanceBlinatumomabCarboplatinCyclophosphamideCytarabineDaunorubicinDexamethasoneDoxorubicinEtoposideIdarubicinIfosfamideImatinibInotuzumab OzogamicinMercaptopurineMethotrexateNelarabinePeg asparaginasePrednisoloneRituximabVincristineVindesineNo. Substances12345678 RadiotherapySupportive therapySupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateUrsodeoxycholic acidSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateUrsodeoxycholic acidSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateUrsodeoxycholic acidSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneDextrose 5%DimetindenFamotidineFilgrastimFolinic acidFosaprepitantFurosemideGranisetronMesnaNaCl 0.9%ParacetamolPegfilgrastimPotassium chloridePrednisoloneSodium BicarbonateUrsodeoxycholic acidNo. Substances1234567891011141516Protocol classificationTherapy classificationcurrent standardStudy protocol, currentIntensityhigh doseStandard doseTherapy indicationFirst lineRelapse therapyTherapy phaseConsolidationInductionMaintenancePre-phaseReinductionTherapy intentioncurativedisease controlRisksAnemia Hb below 8g/dlBleedingConstipationEmetogenicityEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)FatigueFebrile NeutropeniaHeadacheHyperbilirubinemiaHyperglycemiaHypokalemiaInfectionsMucositisNeutropeniaOral MucositisThrombocytopenia below 50 000/µlVOD/SOS only studiesPublicationAuthorDavies AGriffin TCGökbuget DGökbuget NHoelzer DJabbour ERausch CRDiseaseAkute lymphatische Leukämie, 18-55 JahreAkute lymphatische Leukämie, lymphoblastische Lymphome, 18-55 JahreAkute lymphatische Leukämie, lymphoblastische Lymphome, 56-75 JahreHochmaligne B-ALL/T-ALL und Burkitt-Lymphom bei Erwachsenen, ErstlinieHochmaligne B-ALL bei Erwachsenen, RezidivtherapieHochmaligne B-ALL und B-NHL bei Erwachsenen, ErstliniePrimär therapierefraktäres oder rezidiviertes B-NHL oder B-ALL, <21 Jahre, ECOG 0-2OriginCancer Research UK Centre, University of Southampton, UK, SABRINA StudieDivision of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, TexasGerman Multicenter Study Group for Adult Acute Lymphoblastic LeukemiaGerman Multicenter Study Group for Adult Acute Lymphoblastic Leukemia, GMALL 07/2017Memorial Hospital of South Bend, South BendThe University of Texas MD Anderson Cancer Center, Houston, USAProtocols in Revision 50 protocols foundProtocols under revision.Blinatumomab (9/28), ALL/NHL, cycle 1 (PID2117 V1.0)Blinatumomab 28, ALL/NHL, cycle 2-4 (PID2118 V1.0)Cytarabine 500 / Methotrexate 250 / Inotuzumab Ozogamicin 0.3 / Rituximab 375, ALL/NHL, cycle 2,4 (PID2097 V1.1)GMALL 08/2013 - ALL maintenance, 18 - 55 years old (PID638 V2.1)GMALL 08/2013 - ALL/LBL consolidation III and V (weeks 24, 32), 18 - 55 years (PID634 V2.0)GMALL 08/2013 - ALL/LBL Consolidation IV (Week 30), 56 - 75 years (PID1097 V1.0)GMALL 08/2013 - ALL/LBL Induction I (Day 6), 18 - 55 years, all risk groups (PID592 V2.0)GMALL 08/2013 - ALL/LBL Induction I (Day 6), 56 - 75 years (PID1087 V1.1)GMALL 08/2013 - ALL/LBL Induction II (Day 20), 56 - 75 years (PID1088 V1.1)GMALL 08/2013 - ALL/LBL Induction II (Day 23), 18 - 55 years, all risk groups (PID594 V2.0)GMALL 08/2013 - ALL/LBL consolidation I (day 60), 18 - 55 years, all risk groups (PID595 V3.0)GMALL 08/2013 - ALL/LBL Consolidation I (Week 9), 56 - 75 years (PID1086 V1.0)GMALL 08/2013 - ALL/LBL Consolidation II (Week 14), 18 - 55 years (PID1098 V1.0)GMALL 08/2013 - ALL/LBL Consolidation II (Week 15), 56 - 75 years (PID1091 V1.1)GMALL 08/2013 - ALL/LBL consolidation III and V (week 24,34), 56 - 75 yrs (PID1090 V1.1)GMALL 08/2013 - ALL/LBL consolidation IV and VI (weeks 27, 35), 18 - 55 yrs (PID632 V2.1)GMALL 08/2013 - ALL/LBL Reinduction (Week 19), 18 - 55 years (PID636 V2.1)GMALL 08/2013 - ALL/LBL Reinduction (Week 19), 56 - 75 years (PID1096 V1.1)GMALL 08/2013 - ALL/LBL Pre-phase, 18 - 55 yrs (PID591 V2.0)GMALL 08/2013 - ALL/LBL Pre-phase, 56 - 75 yrs (PID1085 V1.0)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part A (PID344 V1.2)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part B (PID346 V1.2)GMALL 08/2013 - B-ALL/NHL 2002 Regimen, 18 - 55, Part C (PID347 V1.1)GMALL 08/2013 - B-ALL/NHL 2002 regimen, all ages, Pre-phase (PID345 V1.0)GMALL 08/2013 - B-ALL/NHL 2002 regimen, Rituximab consolidation (PID784 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 5 (PID2087 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Ddoxorubicin 50 / Dexamethasone 40) / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 7 (PID2089 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 400, ALL/NHL, Ph/BCR-ABL+, intensification, month 7,19 (PID2113 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 3 (PID2086 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375 / Imatinib 800, ALL/NHL, Ph/BCR-ABL+, cycle 1 (PID2084 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40) / Rituximab 375, ALL/NHL, cycle 1,3 (PID2061 V1.0)Hyper-CVAD (Cyclophosphamide 300 / Vincristine 2 / Doxorubicin 50 / Dexamethasone 40), ALL/NHL, cycle 5,7 (PID2063 V1.0)Methotrexate 100 / Peg-asparaginase 2000 / Imatinib 400, ALL/NHL, Ph/BCR-ABL+, intensification, month 6,18 (PID2110 V1.1)Methotrexate 100 / Peg-asparaginase 2000, ALL/NHL, intensification, month 6,18 (PID2074 V1.1)Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 6 (PID2088 V1.1)Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 8 (PID2090 V1.1)Methotrexate 1000 / Cytarabine 3000, ALL/NHL, cycle 6,8 (PID2065 V1.1)Methotrexate 15 / Cytarabine 30, Burkitt's Lymphoma (PID2240 V1.1)Mini-hyperCVD (Cyclophosphamide 150 / Vincristine 2 / Dexamethasone 20) / Inotuzumab Ozogamicin (0.6/0.3) / Rituximab 375, ALL/NHL, cycle 1 (PID2098 V1.0)Mini-hyperCVD (Cyclophosphamide 150 / Vincristine 2 / Dexamethasone 20) / Inotuzumab Ozogamicin 0.3 / Rituximab 375, ALL/NHL, cycle 3 (PID2099 V1.0)Nelarabine 650 / Peg-asparaginase 1500, T-ALL, maintenance, month 6, 7 (PID2083 V1.1)POMP (Mercaptopurine 50 / Methotrexate 10), ALL/NHL, maintenance, month 13-36, variant 1 (PID2120 V1.0)POMP (Mercaptopurine 50 / Vincristine 2 / Methotrexate 10 / Prednisolone 50), ALL/NHL, maintenance, month 1-12, variant 1 (PID2119 V1.0)POMP (Mercaptopurine 50 / Vincristine 2 / Methotrexate 20 / Prednisolone 200), ALL/NHL, maintenance, month 1-5,8-17,20-30 (PID2072 V1.0)R-ICE - Rituximab 375 / Etoposide 100 / Carboplatin 5 / Ifosfamide 3, Burkitt's Lymphoma, Cycle 1-2. (PID2223 V1.0)R-ICE - Rituximab 375 / Etoposide 100 / Carboplatin 5 / Ifosfamide 3, Burkitt's Lymphoma, Cycle 3. (PID2224 V1.0)Rituximab 1400, single dose subcutaneous (PID310 V2.0)Rituximab 375 / Methotrexate 1000 / Cytarabine 3000 / Imatinib 600, ALL/NHL, Ph/BCR-ABL+, cycle 2,4 (PID2085 V1.1)Rituximab 375 / Methotrexate 1000 / Cytarabine 3000, ALL/NHL, cycle 2,4 (PID2064 V1.1)Vincristine 2 / Prednisolone 200 / Imatinib 400, ALL/NHL, maintenance, Ph/BCR-ABL+ (PID2073 V1.0)
