Search Protocols under revision. Back New search Go to resultsDiseaseMain groupHematologic NeoplasmsProtocol groupAcute LeukemiasDiseaseAcute Promyelocytic LeukemiaSubgroupICD10C92.4-MeSHLeukemia, Promyelocytic, AcuteSequenceAPL2016, arm A1: APL2006 V4.1 - A1, A2 and A3, Ind., APL, up to 70, leukoc. up to 10000/µl (PID1035) -|- 1st cons. (PID1042) -|- 2nd cons. (PID1043) -|- maint. (PID1053)APL2016, arm A2: APL2006 V4.1 - A1, A2 and A3, Ind., APL, up to 70, leukoc. up to 10000/µl (PID1035) -|- 1st cons. (PID1044) -|- 2nd cons. (PID1045) -|- maint. (PID1053)APL2016, arm A3: APL2006 V4.1 - A1, A2 and A3, Ind., APL, up to 70, leukoc. up to 10000/µl (PID1035) -|- 1st cons. (PID1046) -|- 2nd cons. (PID1047) -|- maint. (PID1053)APL2016, Arm B: APL2006 V4.1 - B - Ind., APL, older 70, leukoc. up to 10000/µl (PID1054) -|- 1st cons. (PID1055) -|- 2nd cons. (PID1056) -|- maint., C1 (PID1057) -|- maint., C2-5 (PID1058) -|- maint., C6-8 (PID1062)APL2016, arm C1: APL2006 V4.1 - C1 and C2, Ind., APL, up to 70, leukoc. above 10000/µl (PID1048) -|- 1st cons. (PID1049) -|- 2nd cons. (PID1050) -|- maint. (PID1053)APL2016, arm C2: APL2006 V4.1 - C1 and C2, Ind., APL, up to 70, leukoc. over 10000/µl (PID1048) -|- 1st cons. (PID1051) -|- 2nd cons. (PID1052) -|- maint. (PID1053)APL2016, Arm D: APL2006 V4.1 - D - Ind., APL, over 70, leukoc. over 10000/µl (PID1059) -|- 1st cons. (PID1060) -|- 2nd cons. (PID1061) -|- maint., C1 (PID1057) -|- maint., C2-5 (PID1058) -|- maint., C6-8 (PID1062)APOLLO, Arm A: IDAR12/TRET22.5/ARSE0.15, APL, Ind. (PID2996) -|- TRET22.5/ARSE0.15, Cons., C1-3 (PID2997) -|- TRET22.5/ARSE0.15, Cons., C4 (PID2998)LPA2005: TRET22.5/IDAR12, APL ind., high-risk (PID1118) -|- 1st cons. (PID1115) -|- 2nd cons. (PID1116) -|- 3rd cons. (PID1117) -|- maint. (PID1119)TRET45/ARSE0.15, Ind., APL (PID652) -|- Cons., C1-3 (PID653) -|- Cons., C4 (PID656)ChemotherapyChemo-substanceArsenic TrioxideCytarabineDexamethasoneIdarubicinMercaptopurineMethotrexateMethylprednisoloneMitoxantroneTretinoinChemo-substanceArsenic TrioxideCytarabineDexamethasoneIdarubicinMercaptopurineMethotrexateMethylprednisoloneMitoxantroneTretinoinChemo-substanceArsenic TrioxideCytarabineDexamethasoneIdarubicinMercaptopurineMethotrexateMethylprednisoloneMitoxantroneTretinoinChemo-substanceArsenic TrioxideCytarabineDexamethasoneIdarubicinMercaptopurineMethotrexateMethylprednisoloneMitoxantroneTretinoinNo. Substances23456 RadiotherapySupportive therapySupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneGranisetronPosaconazolePrednisoloneSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneGranisetronPosaconazolePrednisoloneSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneGranisetronPosaconazolePrednisoloneSupportive substanceAmphotericin BBalanced Crystalloid SolutionCiprofloxacinCotrimoxazoleDexamethasoneGranisetronPosaconazolePrednisoloneNo. Substances123456Protocol classificationTherapy classificationcurrent standardStudy protocol, currentIntensityhigh doseStandard doseTherapy indicationFirst lineTherapy phaseConsolidationInductionMaintenanceTherapy intentioncurativeRisksAnemia Hb below 8g/dlAnemia Hb below 10g/dlBleedingDifferentiation syndromeDyspneaEmetogenicityEmetogenicity (ASCO)Emetogenicity (MASCC/ESMO)Febrile NeutropeniaHepatotoxicityInfectionsNeutropeniaPainQTc Time ExtensionRashRenal FailureSeizuresThrombocytopenia below 50 000/µl only studiesPublicationAuthorAvvisati GFenaux PLo-Coco FPlatzbecker U Sanz ADiseaseAktue Promyelozyten Leukämie, Hochrisiko (Leukozyten >10 000/µl), ECOG 1-3Akute Promyelozyten Leukämie, Hochrisiko, 18-65 J., ECOG 0-3, Leukozyten bis 10000/µlAPL mit t(15;17) und/oder PML-RARA Rearrangement, Erstlinieniedriges bis mittleres Risiko der akuten Promyelozyten Leukämie, ECOG 0-2OriginEuropean APL GroupGIMEMA, AIEOP, and EORTC Cooperative Groups, AIDA 0493GIMEMA, AMLSG und SAL, APL0406Hospital Universitario La Fe, Valencia, SpainUniversity Hospital Carl Gustav Carus and TU Dresden, Dresden, Germany, APOLLO trialProtocols in Revision 33 protocols foundAPL2006 V4.1 - A1 - Idarubicin 12 / Cytarabine 200, 1st consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1042 V1.0)APL2006 V4.1 - A1 - Idarubicin 9 / Cytarabine 1000, 2nd consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1043 V1.0)APL2006 V4.1 - A1, A2 and A3, Tretinoin 45 / Idarubicin 12 / Cytarabine 200, induction, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1035 V1.0)APL2006 V4.1 - A1, A2, A3, C1, and C2 - Mercaptopurine 90 / Methotrexate 15 / Tretinoin 45, maintenance, Acute Promyelocytic Leukemia, up to 70 years of age (PID1053 V1.0)APL2006 V4.1 - A2 - Idarubicin 12 / Arsenic Trioxide 0.15, 1st consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1044 V1.0)APL2006 V4.1 - A2 - Idarubicin 9 / Arsenic Trioxide 0.15, 2nd consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1045 V1.0)APL2006 V4.1 - A3 - Tretinoin 45 / Idarubicin 12, 1st consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1046 V1.0)APL2006 V4.1 - A3 - Tretinoin 45 / Idarubicin 12, 2nd consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes up to 10000/µl (PID1047 V1.0)APL2006 V4.1 - B - Idarubicin 9 / Arsenic Trioxide 0.15, 1st consolidation, Acute Promyelocytic Leukemia, older than 70 years, leukocytes up to 10000/µl (PID1055 V2.0)APL2006 V4.1 - B - Tretinoin 45 / Arsenic Trioxide 0.15, 2nd consolidation, Acute Promyelocytic Leukemia, older than 70 years of age, leukocytes up to 10000/µl (PID1056 V1.0)APL2006 V4.1 - B - Tretinoin 45 / Idarubicin 9, induction, Acute Promyelocytic Leukemia, older than 70 years, leukocytes up to 10000/µl (PID1054 V1.0)APL2006 V4.1 - B and D, Arsenic Trioxide 0.15, maintenance, Acute Promyelocytic Leukemia, older than 70 years, cycle 2-5 (PID1058 V1.0)APL2006 V4.1 - B and D, Mercaptopurine 90 / Methotrexate 150 / Tretinoin 45, maintenance, Acute Promyelocytic Leukemia, older than 70 years, cycle 1 (PID1057 V1.0)APL2006 V4.1 - B and D, Mercaptopurine 90 / Methotrexate 150 / Tretinoin 45, maintenance, Acute Promyelocytic Leukemia, older than 70 years, cycle 6-8 (PID1062 V1.0)APL2006 V4.1 - C1 - Idarubicin 12 / Cytarabine 200, 1st consolidation, Acute Promyelocytic Leukemia, up to 70, leukoc. over 10000/µl (PID1049 V1.0)APL2006 V4.1 - C1 - Idarubicin 9 / Cytarabine 1000, 2nd consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes over 10000/µl (PID1050 V1.0)APL2006 V4.1 - C1 and C2, Tretinoin 45 / Idarubicin 12 / Cytarabine 200, induction, Acute Promyelocytic Leukemia, up to 70 years, leukocytes over 10000/µl (PID1048 V1.0)APL2006 V4.1 - C2 - Idarubicin 12 / Arsenic Trioxide 0.15, 1st consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes over 10000/µl (PID1051 V1.0)APL2006 V4.1 - C2 - Idarubicin 9 / Arsenic Trioxide 0.15, 2nd consolidation, Acute Promyelocytic Leukemia, up to 70 years, leukocytes over 10000/µl (PID1052 V1.0)APL2006 V4.1 - D - Idarubicin 9 / Arsenic Trioxide 0.15, 1st consolidation, Acute Promyelocytic Leukemia, over 70 years, leukocytes over 10000/µl (PID1060 V1.0)APL2006 V4.1 - D - Tretinoin 45 / Arsenic Trioxide 0.15, 2nd consolidation, Acute Promyelocytic Leukemia, over 70 years, leukocytes over 10000/µl (PID1061 V1.0)APL2006 V4.1 - D - Tretinoin 45 / Idarubicin 9 / Cytarabine 120, induction, Acute Promyelocytic Leukemia, over 70 years, leukocytes over 10000/µl (PID1059 V1.0)Idarubicin 12 / Tretinoin 22.5 / Arsenic Trioxide 0.15, Acute Promyelocytic Leukemia, Induction (PID2996 V1.0)Tretinoin 22.5 / Arsenic Trioxide 0.15, Acute Promyelocytic Leukemia, consolidation, cycle 1-3 (PID2997 V1.0)Tretinoin 22.5 / Arsenic Trioxide 0.15, Acute Promyelocytic Leukemia, consolidation, cycle 4 (PID2998 V1.0)Tretinoin 22.5 / Idarubicin 12, Acute Promyelocytic Leukemia, induction, high risk (PID1118 V2.0)Tretinoin 45 / Arsenic Trioxide 0.15, Induction, Acute Promyelocytic Leukemia (PID652 V1.1)Tretinoin 45 / Arsenic Trioxide 0.15, consolidation, Acute Promyelocytic Leukemia, cycle 1-3 (PID653 V1.1)Tretinoin 45 / Arsenic Trioxide 0.15, consolidation, Acute Promyelocytic Leukemia, cycle 4 (PID656 V1.1)Tretinoin 45 / Idarubicin 12 / Cytarabine 150, Acute Promyelocytic Leukemia, 3rd consolidation, high risk (PID1117 V1.0)Tretinoin 45 / Idarubicin 5 / Cytarabine 1000, Acute Promyelocytic Leukemia, 1st consolidation, high risk (PID1115 V1.0)Tretinoin 45 / Mercaptopurine 50 / Methotrexate 15 , Acute Promyelocytic Leukemia, maintenance, high risk (PID1119 V1.0)Tretinoin 45 / Mitoxantrone 10, Acute Promyelocytic Leukemia, 2nd consolidation, high risk (PID1116 V1.0)
